The only book on your list that I've finished (even read parts in Spanish). I'm going to disagree. DQ is the most relevant of novels, a pre and post modern fiction (At the beginning of Volume 2, Don Quixote and Sancho Panza discuss the reception of DQ volume 1.) Imo, all of the conflicts in the novel are relevant today (themes like patriarchy vs. the rights of women, introduced with the episode of the shepherdess Marcela). You just have to figure out how to co-ordinate the actions in the novel with the struggles people face today.

DQ has two narrators, btw--a Spanish narrator who reports on notes by a Moorish narrator. The irony is that the Spanish narrator questions the veracity of the original tale (since the primary narrator is not Christian) , but it becomes clear that the Spanish narrator is superimposing his own prejudices on the story.