Just plain brilliant as a series of guidelines.

I haven't kept up with script buying for quite a while, and you may have addressed this issue elsewhere, so apologies in advance for what is an uninformed question:

Assuming that one has a well-written story that doesn't fit the currently popular tentpole genres but that follows these new quadrants, have the optimal marketing / submission strategies changed as well? I know there's no single best way to submit an independent spec script to an independent prodco, but have new paths opened up? Have old paths closed?