Do you know the theory of the French philosopher Henri Bergson? He argued that we laugh at people when they act in mechanical (predictable, repeated) ways (this would be true of Wile E. Coyote, and many of the others you list here). Perhaps comedy heals (and leads to longevity) because it encourages us to be more flexible.

https://aeon.co/essays/for-henri-bergson-laughter-is-what-keeps-us-elastic-and-free